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School Of Music – La Escuela de la Guitarra Don’t see what you’re looking for? Get a sample pack from this artist! All of these packs are in Zip format, so all you have to do is open them in your favourite WinZip, WinRAR or another program of similar nature. If you do not have one of those, you can easily download the zip file to your computer and unzip it. Once unzipped, you can delete the ZIP file. You can choose to download the entire pack to your computer. This will add all of the samples to your iTunes library but you will need to sync your library to listen to them. You can also choose to download samples that you want to use right away. Just drag and drop the actual songs into your digital music player to listen to them. If you have any problems with downloading, please get in touch and we’ll sort it out for you. All sample packs are free to download and most are exclusive to AudioJungle.Involvement of astrocytes in the regulation of the passive and active uptake of uric acid by the brain. Urate, the major end product of purine metabolism, may either be degraded or excreted from the brain. The brain has high capacity for urate accumulation and excretion, which is carried out by a combination of apical and basolateral transport. We investigated the role of astrocytes in both the uptake and efflux of urate. Urate accumulation by rat astrocytes, grown in primary culture, increased linearly up to a concentration of 1 mM and a maximal active transport Km of 450 microM urate. When cells were preincubated with an ATP-regeneration system, no accumulation was observed. Urate was effluxed from cultured rat astrocytes to a much greater extent than from cortical tissue slices. However, there was no difference in the inhibitory concentration of urate in the astrocyte and tissue slice preparations. We propose that in the brain, urate is actively transported from the capillary surface into neurons, from which point the active transport process decreases and the transcellular movement predominates. From here, there is a marked reversal of direction and net efflux of urate into the perivascular spaces. We conclude that at physiological concentrations and membrane potential, the uptake of urate by astrocytes is not important

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